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IGFBP-7 inhibits the senescence process of dental pulp-derived mesenchymal stem cells (MSCs) while promoting osteogenic differentiation [69]

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Further, activation of the AT 1 receptor results in the stimulation of the NF-kB signal transduction pathway facilitating the synthesis of chemokine, cytokines, and adhesion molecules, all important in the migration of inflammatory cells into regions of tissue injury (107)