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There is an exchange of lactate between two different regions within the tumor microenvironment the hypoxic region and the normoxic region

1 Among various types of stem cells, mesenchymal stem cells (MSCs) have garnered significant interest because of their unique biological properties, versatility, and clinical safety profile

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The sam1/sam1 mutant cells likely exhibited decreased growth in this condition due to downregulated CDC21 expression (fold change of 0.62, p-value=0.0247), which encodes thymidylate synthase, and/or because RNR complex inhibition could create dNTP pool imbalances which in concert with less Cdc21 could cause more difficulty to interconvert between some deoxyribonucleotides in these mutant cells, thereby creating sensitivity to this condition (Fig 13)

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