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Lower life expectancy due to accidents on road and workplace
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Wang L, van Iersel LEJ, Pelgrim CE, Lu J, van Ark I, Leusink-Muis T, et al

Additionally, immunomodulatory agents like tofacitinib, a JAK inhibitor, carry risks of increased susceptibility to infections, particularly in immunocompromised individuals, as well as potential cardiovascular and thromboembolic events [153]
