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Here we affirm the pharmacological potential of NMDA receptor channel blockers for obesity treatment (Extended Data Fig

[DOI] [PMC free article] [PubMed] [Google Scholar] 25.Vukojevic J., Vrdoljak B., Malekinusic D., Siroglavic M., Milavic M., Kolenc D., Boban Blagaic A., Bateljam L., Drmic D., Seiwerth S., et al

[DOI] [PMC free article] [PubMed] [Google Scholar] Danielsson BRG, Dencker L, Orsen I, Khayat A

Furthermore, E362 is nearby C326 and likely keeps the cysteine reduced for covalent attack of the aldehyde, as evidenced by the reduced activity upon its substitution (E362A)