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Antioxidants such as SOD, ascorbic acid, vitamin E, melatonin, alpha-lipoic acid, peroxynitrite decomposition catalyst, and gamma-linolenic acid have been identified as attenuating autonomic neuropathy and diabetic vasculopathy in the penis, thereby improving overall erectile function to various extents [186,187,188,189,190,191]

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The NNT encoded enzyme utilizes the energy of the mitochondrial proton gradient (the proton motive force) to catalyze hydride transfer from NADH to NADP + generating NADPH

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