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ROSMAP microglia analysis The ROSMAP snRNA-seq data were processed, analyzed and annotated by Mathys et al 89

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Statistical analysis All analyses were conducted using the RStudio version 1.4.17.17 software by the packages meta and metafor. We used the method suggested by the Cochrane handbook to calculate the sample size and event [19]

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Every biological replicate consisted of three technical replicates