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PRMT5 is highly expressed in breast cancer and chronic myeloid leukemia (CML) stem cells, and the knockdown of PRMT5 or the use of PRMT5 inhibitors can significantly impair the self-renewal capacity of CSCs

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however, none has been further evaluated in animal models, and thus, it remains unclear whether they will be effective in vivo

Dietary L-carnitine affects periparturient nutrient metabolism and lactation in multiparous cows

Dec 2017;96(49):e9061