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The increasing prevalence of conditions such as ADHD has paralleled the increase in diet-related health issues, with exposure to nutritional factors during or even prior to pregnancy being important [174]

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90,91 Additionally, the activity of epigenetics-modifying enzymes and their cofactors, such as TET and -ketoglutarate (-KG) from the tricarboxylic acid cycle (TCA), can be influenced by abnormal metabolite levels in patients with metabolic diseases, further disrupting epigenetic regulation and exacerbating disease progression

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doi: 10.3389/fmars.2019.00760 69 KalananthanTGomesASLaiFTolsIJordalA-ENorlandSet al
