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Overall, structural alterations found in SURF1 and other LS mutant organoids confirmed the dysregulation of NPCs function and morphogenesis as a relevant mechanism in the pathophysiology of LS

These radiologic distinctions help differentiate fibrotic HP from UIP/IPF, which tends to show uniform lower-lobe involvement (Barnes et al ., 2022

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p53 controls the mTOR pathway at multiple levels, including direct regulating signaling mechanisms, posttranscriptional regulation by miRNAs, and inhibiting autophagy through proteinprotein interaction [56]

Together, they cover three complementary pathways relevant to skin and tissue biology research