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The principal mechanism driving AOPPs generation involves the activated myeloperoxidase-H 2 O 2 -chloride system in neutrophils, with myeloperoxidase serving as the sole enzyme capable of generating chlorinated oxidants (Figure 2) (72, 73)

10.1038/s41598-022-23433-0 70 ConveryN.GadegaardN

Note that commercial payers might not adopt all of the same coding changes as Medicare does, and it is impossible to summarize here the effect on their payment policies

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Triggering of a neutrophil by either PMA or fMLP leads to the phosphorylation of P47phox, a cytosolic subunit of NADPH complex and translocate to the plasma membrane to interact with flavocytochrome b558 [71,72,73]