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PDGF and TGF- secreted by sprouting endothelial cells drive the accumulation and activation of HSCs around endothelial cells

Although the exact reasons are not known, we hypothesize that this could be an effect of the increased density and stiffness of the material, both of which have been shown in previous studies to have potentially detrimental impacts upon cellular migration and axonal elongation across nerve gaps 32,33,35,36,37

In vitro studies first showed that Mn exposure (above 10 M) induces apoptosis in dopaminergic neurons (Latchoumycandane et al., 2005) and the PC12 cell line, a common model for neurons (Hirata, 2002

To identify the nozzles from M
