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Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions

they mediate visceral nociception, and are activated by mechanical and chemical irritants in the upper airways, transmitting to the brainstem nuclei and central nervous system (CNS) (Mazzone and Undem 2016)

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Activated microglia (M1) often release inflammatory and neurotoxic compounds such as reactive oxygen species (ROS), nitric oxide, TNF-, and IL-6

The S-acetyl modification serves two purposes: it makes the molecule more stable and resistant to degradation in the GI tract, and it may help the molecule cross cell membranes more easily than unmodified reduced glutathione