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The only established clinical application of Selenium supplementation therapy is currently Thyroid Eye Disease (TED) [88,89,90]

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This shortage inhibits tissue uptake, resulting in reduced accumulation in the skeletal muscle and heart, as well as potentiating increased renal carnitine loss (Burwinkel et al., 1999, Y et al.., 1999), resulting in systemic carnitine depletion (Reuter et al., 2008)

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