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It prevents bacterial growth and prolongs the viability of the mixed solution

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Symptoms of hip osteoarthritis include persistent hip pain, especially during or after movement, stiffness in the hip joint after periods of inactivity or rest, and reduced range of motion

Endocrinology 152 , 181192 (2011)

However, it is necessary to consider that the introduction of a new amide bond increases the susceptibility to hydrolysis and the topological polar surface area (TPSA), as well as contributing to the increase of hydrogen bond donor (HBD) or hydrogen bond acceptor (HBA) count