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Patient factors including skin type, location, age & psychological impact are taken into consideration

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Park KM, Kim B, Woo W, Kim LK, Hyun YM
After being boosted through precursor supplementation, NAD+ often plateaus and declines around week 12, which is likely due to an overabundance of NAM (a byproduct of NAD+) and a shortage of methyl donors present to fuel conversion in the salvage pathway.38 Supplementing with a potent methyl donor can offset this shortage and ensure sustained activity in the salvage pathway
