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However, the current injectable protein therapies have associated risks and limitations

Whilst the specific molecular structure of this pathway is less understood than the pore pathway, it is thought to be regulated by occludin, tricellulin, ZO-1, and perijunctional actomyosin [19, 33], although there is evidence that alterations in tricellulin expression may affect permeability of this pathway [34]

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These findings have generated hypotheses for future investigation, but they should not be interpreted as demonstrating established clinical benefits in humans