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Every time the needle goes through the stopper is a chance to introduce bacteria

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For patients receiving intramuscular B12 injectionsthe standard treatment for pernicious anaemia and severe deficiency neurological symptoms may start improving within one to two weeks , whilst haematological parameters typically normalise within approximately eight weeks

Also, consult a healthcare professional to design an appropriate protocol for your needs

[PubMed] [Google Scholar] 52.Yang P, Ebbert JO, Sun Z, Weinshilboum RM