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Rare allergic reactions (particularly in individuals sensitive to sulfa, due to methionine)

Rivaroxaban also had lower rates of intracranial bleeding compared to apixaban, but higher rates of gastrointestinal bleeding

doi:10.2337/dc11-1582

A single-nucleotide polymorphism (sA158G rs4680) in the COMT gene also led to a greater risk of LDopa-related PN in PwPD through low enzymatic activity (Toth et al
