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These substances are electrophiles and form conjugates with GSH, either spontaneously or enzymatically, in reactions catalyzed by GSH- S -transferases (GST) [22]

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1 Unlike other vitamins, vitamin B12 is not produced by the body and must be obtained through food intake and supplementation

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Livers from patients, who overdosed on acetaminophen, exhibit upregulation of ABCC1 and ABCC4 mRNAs and elevated protein levels of ABCB1, ABCG2, ABCC4 and ABCC5