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Tirzepatide is a glucagon-like peptide-1 (GLP-1) receptor agonist for chronic weight management, along with a reduced calorie diet and increased physical activity, for people with an initial body mass index (BMI) of: 30 kg/m2 or greater (obesity) or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)

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Weight gain associated with hypothyroidism often improves once thyroid hormone levels are adequately replaced, so it is worth confirming that your current levothyroxine dose is appropriate before pursuing additional weight management interventions