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At C$145.00 for 10mg total, the per-mg math is straightforward: CagriSema blend at C$145.00 / 10mg = C$14.50 per mg of total peptide That C$14.50/mg figure is what should be compared across suppliers (not the per-vial price), and it's also the right number to use when comparing CagriSema to the single-component GLP-1 peptides: CagriSema is at the higher end of the per-mg range, which makes mechanistic sense: it's a two-component product, and cagrilintide is a more complex peptide than semaglutide

HGMD: CM166199, ClinVar: RCV000239469.1604327.007, OMIM #604327.007) - further confirming the variable phenotypic spectrum associated with pathogenic variants in this gene