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Description
The story of AOD 9604 didn't end with the failed Phase IIb trial
Despite its importance, many people are deficient in this essential vitamin, leading to a range of health issues
AOD-9604 should be avoided or used only under close medical supervision in certain populations
Furthermore, using a murine cholangitis model, the researchers clarified the underlying mechanisms: butyrate activates peroxisome proliferator-activated receptor delta (PPARD) to promote fatty acid -oxidation (FAO)-mediated metabolic reprogramming
The most comprehensive study, published in BioMed Research International (2021), found that 5-amino-1MQ treatment "reverses diet-induced obesity and related T2D" in obese mice
