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Therapeutic potentials of catalase: Mechanisms, applications, and future perspectives

Common practice splits the daily amount into once or twice daily doses

Consistent with perturbed glutathione metabolism, CLP mice exhibited significant downregulation of the Nrf2/HO-1 antioxidant axis: reduced Nrf2, a master transcriptional regulator of antioxidant genes, and its target HO-1 were reduced, indicating impaired upstream antioxidant regulation

Kyriacou A, Ahmed AB

Step 5: Cycle appropriately
