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Taken together, our results establish the SPOC domain as an essential module for PHF3 and DIDO interaction with the Pol II transcription elongation machinery, whereas SHARP and RBM15 SPOC show stronger binding to other proteins

An FDA panel recently voted against the NDA of Qnexa because of safety concerns (Table 3 )

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Future preclinical work may probe combinations with incretin-based agents or -oxidation enhancers to define mechanistic complementarity

Animal studies are promising, showing enhanced healing of connective tissue and protective effects on the digestive tract