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Li and Fantke, 2023)

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10.3969/j.issn.1671-038X.2021.02.14 Chin J West Int Med Trad Dig

One of the primary palliative treatment options for advanced hepatocellular carcinoma is transcatheter arterial chemoembolization (TACE)
Specifically, inactivating DHODH causes significant mitochondrial lipid peroxidation and ferroptosis in cancer cells with low GPX4, likely due to DHODH's role in reducing CoQ to CoQH2 [76]