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When IGF-1 axis is activated, multiple signaling pathways corresponding to its kinase domain are also activated, including PI3K/Akt pathway and Raf/MEK/ERK level linkage pathway, which can ultimately reduce IR and prevent cell apoptosis (58, 59), thereby improving NAFLD

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Data extraction Two researchers independently extracted the required data from the full-text articles, and conflicts were resolved through discussions with a third researcher

10.2174/1570162X11311030007 [DOI] [PubMed] [Google Scholar] 47.Agganis BT, Weiner DE, Giang LM, Scott T, Tighiouart H, Griffith JL, et al