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It is also dependent on the number of areas you want to be treated

Definitely feel a difference in my energy levels however I find I need to take more than twice a week

While all studies adequately ascertained exposure and ensured comparability between outcome groups by controlling for confounders, 42% (n = 5) did not provide adequate sample representativeness and size, and 17% (n = 2) did not report the non-response rate