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The major cause of the loss of intrinsic factor is an autoimmune destruction of the parietal cells that secrete it

Kawoos U, McCarron RM, Chavko M

Each step is a little "upgrade" toward the active form which is part of why Retinol is gentler than prescription Retinoic Acid

injectables may reach higher local concentrations but lack extensive human trial data and FDA approval for this purpose

There is an ongoing discussion about making a finalized decision on United States Pharmacopeia (USP) monographs for maca root, maca root powder, and maca root glucosinolates dry extract based on validated methods of analysis [69]