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A reasonable candidate is someone who: Is already following a structured, clinician-supervised nutrition and activity plan Has a documented B12 deficiency or a condition that impairs B12 absorption Cannot tolerate GLP-1 medications, or is not a candidate for them Declines prescription pharmacotherapy and wants a non-stimulant, non-surgical adjunct Understands because the clinician has said so plainly that the injection is a supporting player A poor candidate is someone who wants the shot instead of the program

CBTmin and DLMO can be used as markers of circadian phase

A total of five participants (mean age: 76+5 years

Ongoing monitoring should be based on individual risk assessment rather than a fixed schedule

Finding your dose sweet spot The optimal dose produces substantial, sustainable weight loss with manageable side effects that do not significantly impair quality of life