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On examination, there was diffuse hyperpigmentation predominantly seen over the face, bilateral forearms, lower legs, palms and soles [Figure 1]

Waldum HL, Kleveland PM, Fossmark R

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Other relevant deficiencies include: Vitamin B12 essential for red blood cell production and nerve function

For anyone reconstituting peptides, hormones, or other lyophilized compounds that require dosing across multiple days, that difference isnt a minor convenience