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6b), indicated a significant downregulation of genes within the transforming growth factor (TGF) signalling pathway, a main regulator of hepatic fibrosis 51 ( Tgfb1 , Tgfb2 , Tgfbr1 and Tgfbr2 ) as well as key genes related to ECM remodelling ( collagen , type I , -1 ( Col1a1 ), Col1a2 and Col4a1 ) in mice overexpressing AGXT

Kwon, N

Systemic infusion of BM-MSCs-EVs in a mouse model of aGVHD can reduce pathological damage to multiple organs targeted by aGVHD and prolong animal survival

Given that these glycoproteins possess numerous essential functions for maintaining astrocyte and neuron stability within the brain, they represent an important factor to consider in the study and treatment of neurological disorders