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Rostami-Nejad M, Razzaghi Z, Esmaeili S, Rezaei-Tavirani S, Akbarzadeh Baghban A, Vafaee R

Regular workouts, balanced nutrition, hydration, sleep, and long-term discipline usually play a much bigger role than focusing only on supplement timing.

In HFD-fed KK-Ay mice, L-carnitine administration inhibited Srebp1c mRNA overexpression while increasing -hydroxybutyrate levels, suggesting concurrent lipogenesis suppression and -oxidation activation (33) provided mechanistic depth by demonstrating that carnitine orotate complex increases carnitine acetyltransferase (CrAT) and -oxidation-related proteins (CPT1, PPAR, UCP2) while inhibiting SREBP1c nuclear translocation and downstream target gene expression ( Hmgcr, Srebp2, Pcsk9, Ldlr ) in HFD-fed mice