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9 Cigarette smoke alone is sufficient to oxidize alpha-1 antitrypsin and damage DNA

Ferroptosis is an iron-dependent PCD, characterized by the elevation of intracellular iron ion levels that generate massive ROS through the Fenton reaction, along with the depletion of the antioxidant GSH, which subsequently trigger lipid peroxidation

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Figure 4 4.2.1 Mechanisms of neuronal ferroptosis after intracerebral hemorrhage Due to the presence of the bloodbrain barrier (BBB), iron entry into the brain is tightly regulated

23 IICA Instituto Interamericano de Cooperacon para la Agricultura (1987)