glutathione s tansferase Frontiers RCSB PDB - 1GNW: STRUCTURE
Description
Main limitation: selectivity figures (such as an in-vitro ~11.7-fold preference for senescent cells) come from cell models, not humans
Within the nucleus, Nrf2 heterodimerizes with small Maf proteins and binds to cis-regulatory DNA sequences termed Antioxidant Response Elements (AREs)
Certain therapies may not be appropriate during pregnancy or breastfeeding
Generally, amino acids residues mitigate oxidation by capturing free radicals as hydrogen donors, chelating oxidative metal ions, and inhibiting lipid peroxidation reactions, etc
R.SpagnolV.et al (2020)
