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Biochem Pharmacol 34:22052207 Roman HB, Hirschberger LL, Krijt J, Valli A, Koich V, Stipanuk MH (2013) The cysteine dioxgenase knockout mouse: altered cysteine metabolism in nonhepatic tissues leads to excess H 2 S/HS- production and evidence of pancreatic and lung toxicity

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Indeed, exogenous H 2 O 2 induces the formation of heterodimers between coactivators (p300 and CBP (CREB-binding protein) acetyltransferases) and FoxO4 through intermolecular disulfide bridges between redox-sensitive cysteine residues and stimulates acetylation of FoxO4 [150]

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