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MC4R activation in renal tubular epithelium increases water reabsorption through aquaporin-2 channel upregulation, producing mild fluid retention (0.51.5 kg weight gain) in 812% of subjects over 714 days of repeated dosing

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[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Karimi H, Ranjbar Saraskanroud M, Balazadeh KF