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To study the effect of BCAT2 inhibition in a whole-body system, we generated a murine disease model of MMA by monoallelic CRISPR targeting to mitigate potential homozygous lethality (see Methods for more details)

Influence of Dietary Ingredients on Lean Body Percent, Uremic Toxin Concentrations, and Kidney Function in Senior-Adult Cats

Low levels of CoQ10 are associated with many diseases

Physical examination was remarkable for lethargy without focal signs

Although the findings are not always consistent, changes in the brainstem have been very common, especially structural changes, mainly a decrease in grey or white matter volume in patients, often pronounced in relation to the symptom burden of fatigue, pain and autonomic symptoms