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The IGF-1/IGF-1R system has been shown to be an important promoter of tumor growth in various cancers, promoting tumor progression and metastasis by regulating multiple signaling pathways, such as those of PI3K/AKT and MAPK/ERK signaling (78,94)

The absorbance of the hematin solutions was measured at 1 nm intervals between 550 nm and 750 nm using a PerkinElmer UV/Vis spectrophotometer Lambda 2 coupled with Lambda25 software

doi: 10.1016/j.redox.2021.101901

We then checked whether the purified TrxR1 might coexist with a Sec498Cys mutant of TrxR1, since under selenium-deficient conditions, the Sec498Cys mutant of TrxR1 was found to be synthesized (Figure 1A

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