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Carotenoids may upregulate the activity of antioxidant enzymes, mainly via the activation of the Nuclear factor erythroid 2-related factor 2 (Nrf2)-dependent pathway (Kaulmann and Bohn 2014)

Journal of Applied Physiology 110(3):774-780
1 2 3 History of Modern Clinical Toxicology

Moreover, DAG extracted from Sargentodoxa cuneate exerts its antioxidant effect by upregulating GPX4 expression and downregulating phosphoextracellular regulated protein kinases and HO-1 expression to counteract APAP-induced ferroptosis in hepatocytes (Liu et al., 2022)
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