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The fact that high levels of peripheral markers of oxidativeinflammatory stress were detected in individuals with MCI lead us to believe that oxidative stress and inflammation are early events in the pathogenesis of AD, and that they precede A deposits and the onset of AD symptoms, which has been shown in experimental models of AD (Ferretti et al., 2012

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doi: 10.1155/2022/2454180 22

Furthermore, the protein corona can cause the physical destabilization and agglomeration of particles

Imaging was conducted using a Leica confocal microscope, allowing for detailed cellular and subcellular localization studies [1]
