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The cycle intermediate 5-oxoproline is found in excess in the bloodstream of these patients, presumably because of the lack of feedback inhibition by GSH on -GCS

TBHQ, tert -butylhydroquinone

EAAC1-deficient mice also showed age-dependent loss of dopaminergic neurons in the substantia nigra pars compacta accompanied by increased oxidative stress [53]

[DOI] [PMC free article] [PubMed] [Google Scholar] 30.Tateishi N., Higashi T., Shinya S., Naruse A., Sakamoto Y

For instance, elevated levels of methylmalonic acid correlate to a vitamin B12 deficiency, which might be caused by pernicious anemia, small intestinal bacterial overgrowth (SIBO), or simply malabsorption