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These include nutritional deficiency due to an unhealthy or poor diet, loss of blood due to heavy periods, internal bleeding, intestinal issues, chronic disorders, genetic disorders, and infections

A deficiency can result in anemia, characterized by reduced oxygen-carrying capacity of the blood

Recent reviews highlight vitamin B12s broader contribution to immune homeostasis and antiviral defense, underscoring its systemic importance beyond hematologic and neurologic functions [4]

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Similarly, the quinolinium containing parent analogue 1-MQ also lacked passive diffusion properties (Table 1), suggesting that the lipophilicity and drug-like permeability properties of analogues within the methylquinolinium series had to be improved via chemical modification