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Furthermore, in vitro studies demonstrated that melatonin can enhance the effect of 5-fluorouracil in colon cancer cells via the activation of caspase-9 and caspase-3 in the mitochondrial apoptotic pathway [160], increasing oxidative stress, downregulating genes and proteins related to apoptosis resistance [161], and inhibiting NF-B/iNOS and PI3K/AKT signaling pathways [162]

There is also evidence that propofol acts on the HIF-1 pathway, a crucial component in the regulation of the growth and proliferation of metastatic tumors

After treatment with bilobalide, the oligomer of -syn were effectively restrained, cell activity was intensified and apoptosis was decreased accordingly

Lists of genes associated with cancers Lists of genes associated with melanoma (73, hsa05218), gastric cancer (150, hsa05226) and thyroid cancer (37, hsa05216) were retrieved from KEGG