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Guyenet SJ, Furrer SA, Damian VM, Baughan TD, La Spada AR, Garden GA

The goal is to maintain a steady level of pain relief so you never hit that painful crash. By alternating the medications every 3 hours (each individual drug taken every 6 hours), you make sure that as one medication dips, the other is reaching its peak

Evidence limitations : Strong rodent data for tendon/muscle repair, but almost no high-quality human trials

However, no research directly compares continuous use versus cycling protocols (such as 12 weeks on, 4-8 weeks off), leaving optimal long-term strategies somewhat uncertain