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From a practical standpoint, GHK-Cus tripeptide-copper complex is water-soluble and can be formulated in aqueous serums, while Matrixyls palmitic acid chain gives it a more lipophilic character suited to cream-based formulations

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The exact pathophysiology remains incompletely understood but involves an exaggerated innate immune response and vasomotor instability leading to abnormal neurovascular signaling