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Within 24 h of administering 500 mL of AI, cumulative urinary excretion of AS-IV reached 3.91%, indicating linear pharmacokinetics within a 200500 mL dose range, with no accumulation observed following once-daily administration of AI (Xu et al., 2013)

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[DOI] [PMC free article] [PubMed] [Google Scholar] 244.Mdkhana B., Goel S., Saleh M.A., Siddiqui R., Khan N.A., Elmoselhi A.B

Given that alcohol and drug addiction are often characterized as compulsive behaviors, it has been repeatedly postulated, albeit with different terminology, that the caudate-putamen, which mediates habit formation and memory, tends to predominate as a memory circuit in late stage dependence (Koob and Volkow, 2010

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