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Once thyroid function is stable, thyroid function tests are typically performed annually, but more frequent testing is warranted during active weight loss

The female mice (homozygous for Hba tm1(HBA)Tow and heterozygous for Hbb tm2(HBG1,HBB*)Tow and Hbb tm3(HBG1,HBB)Tow [h/h:: A / S ], sickle-cell trait mice) and male mice (homozygous for both Hba tm1(HBA)Tow and Hbb tm2(HBG1,HBB*)Tow [h/h:: S / S ], sickle SCD mice) were bred to generate SCD mice
To evaluate the stability and retention of G/D-CuP in vivo, it was topically applied to full-thickness dorsal wounds in diabetic mice
This diagnostic step is crucial for determining the cause of the deficiency and creating an appropriate treatment plan

Both peptides show favorable safety profiles in preclinical studies
