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A variety of pharmacological and genetic inhibitors of ferroptosis have also been reported (Angeli et al., 2017
When it was recognized that pellagra, a condition marked by diarrhea, dermatitis, dementia, and mortality, could be treated with foods containing NAD+ precursors, particularly vitamin B3, the clinical significance of maintaining NAD+ levels was established in the early 1900s (9). Notably, the skin does not flush with NAD+ injection, in contrast to vitamin B3 (niacin) intake, which also causes this negative effect (10). Low NAD+ levels have recently been associated with a variety of age-related ailments and diseases linked to increased oxidative/free radical damage, including diabetes, heart disease, vascular dysfunction, ischemic brain injury, Alzheimers disease, and vision loss (8, 11-17)
2020;10.1038/s41436-020-0899-x
Vaccines (Basel) 2020;8:83
In aged rodent models, treatment reduced lipid peroxidation markers and restored antioxidant enzyme activity to levels comparable to younger animals
