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Among these, Avasopasem manganese (GC4419), a synthetic SOD mimetic, has advanced to phase 2 clinical trials 37 , demonstrating radioprotective effects and significantly reducing the duration, severity, and incidence of severe OM
P., and Groffman, P
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doi: 10.1210/endo.138.3.5103 45 BustinSAJenkinsPJ
(45) found that common deacetylases HDAC1-3 and SIRT1-3 have the ability to eliminate Kla, among which HDAC3 is the most effective eraser for L- and D-lactylation (46) ( Figure 2 )
