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For a deeper look at the biological causes behind dark lips, we cover the five main mechanisms in a dedicated article
Crawford, B
At this early stage, signaling factors of the BMP/WNT family trigger the expression of transcription factors of the Snail, Twist, Fox, Sox, and ETS families, which mediate epithelium-to-mesenchyme transition (EMT), among other functions
20,25 This modality offers precisely targeted treatment with immediate tumor necrosis, and may be a good selection for elderly patients whose tumor meets the recommended treatment criteria
